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NSAIDs, which stands for non-steroidal anti-inflammatory drugs, includes aspirin, ibuprofen, and naproxen. All are effective in treating migraine headaches. Effervescent aspirin is a particularly effective form for controlling pain in migraines. Some people also find that consuming caffeine—in chocolate, coffee, or cola—reduces the intensity of their headache.

Combination over-the-counter medications that contain acetaminophen (known as paracetamol outside the US), aspirin, and caffeine are also effective in migraine relief . Some evidence suggests that this combination of drugs is more effective than a prescription triptan-type medication at aborting the pain of migraine.